Ingredient Research 

Turmeric 

Turmeric 

"Over all significant improvement was observed in the patients of [turmeric] extract group as compared to placebo group. [...] It may be concluded that on chronic administration, [turmeric] suppresses inflammation and brings clinical improvement in patients of [osteoarthritis of the knee], which may be observed by decreased level of IL-1β and VAS/WOMAC scores, respectively. At the same time, [turmeric] decreases the oxidative stress also."

Srivastava S, Saksena AK, Khattri S, Kumar S, Dagur RS. Inflammopharmacology.

2016 Dec;24(6):377-388. Epub 2016 Oct 19.


Inflammation. 2011 Aug;34(4):291-301. doi: 10.1007/s10753-010-9278-0.

Ramadan G, Al-Kahtani MA, El-Sayed WM.


Madhu K, Chanda K, Saji MJ. Inflammopharmacology.

2013 Apr;21(2):129-36. doi: 10.1007/s10787-012-0163-3. Epub 2012 Dec 16.


Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L,

Thamlikitkul V. J Altern Complement Med. 2009 Aug;15(8):891-7. doi: 10.1089/acm.2008.0186.


Park S, Lee LR, Seo JH, Kang S. Genes Nutr.

2016 Mar 17;11:2. doi: 10.1186/s12263-016-0520-4. eCollection 2016.


Jackson JK, Higo T, Hunter WL, Burt HM.  Inflamm Res. 2006 Apr;55(4):168-75.


Piperine

Piperine

"Piperine significantly reduced nociceptive and arthritic symptoms at days 8 and 4, respectively. Histological staining showed that piperine significantly reduced the inflammatory area in the ankle joints. [...] These results suggest that piperine has anti-inflammatory, antinociceptive, and antiarthritic effects."

Jun Soo Bang, Da Hee Oh, Hyun Mi Choi, Bong-Jun Sur, Sung-Jig Lim, Jung Yeon Kim,

Hyung-In Yang, Myung Chul Yoo, Dae-Hyun Hahm, and Kyoung Soo Kim. Arthritis Res Ther. 2009; 11(2): R49.


Ying X, Chen X, Cheng S, Shen Y, Peng L, Xu HZ. Int Immunopharmacol.

2013 Oct;17(2):293-9. doi: 10.1016/j.intimp.2013.06.025. Epub 2013 Jul 6.


Anuthakoengkun A, Itharat A. J Med Assoc Thai. 2014 Aug;97 Suppl 8:S116-24.


Mujumdar AM, Dhuley JN, Deshmukh VK, Raman PH, Naik SR. Jpn J Med Sci Biol. 1990 Jun;43(3):95-100.


Umar S, Golam Sarwar AH, Umar K, Ahmad N, Sajad M, Ahmad S, Katiyar CK, Khan HA. Cell Immunol.

2013 Jul-Aug;284(1-2):51-9. doi: 10.1016/j.cellimm.2013.07.004. Epub 2013 Jul 19.


Tasleem F, Azhar I, Ali SN, Perveen S, Mahmood ZA.  Asian Pac J Trop Med.

2014 Sep;7S1:S461-8. doi: 10.1016/S1995-7645(14)60275-3.


MSM  
(METHYLSULFONYLMETHANE)

MSM

"A randomized, double-blind, placebo-controlled trial was conducted. Fifty men and women, 40-76 years of age with knee OA pain were enrolled in an outpatient medical center. [...] Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05). [...] MSM also produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation (P<0.05).

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF.

Osteoarthritis Cartilage. 2006 Mar;14(3):286-94. Epub 2005 Nov 23.


Van der Merwe M, Bloomer RJ.

J Sports Med (Hindawi Publ Corp). 2016;2016:7498359. Epub 2016 Oct 23.


Notarnicola A, Maccagnano G, Moretti L, Pesce V, Tafuri S, Fiore A, Moretti B.

Int J Immunopathol Pharmacol. 2016 Mar;29(1):140-6. doi: 10.1177/0394632015622215. Epub 2015 Dec 18.


Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B.

Acta Med Indones. 2017 Apr;49(2):105-111.


Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.

BMC Complement Altern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50.


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